Article Per Year (5 Year)
p-Index From 2019 - 2024
1.376
P-Index
This Author published in this journals
All Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI Lantanida Journal Chimica et Natura Acta Jurnal Kreativitas PKM Jurnal Ilmiah Farmako Bahari
Riza Apriani
Department Of Chemistry, Faculty Of Mathematics And Natural Science, Universitas Garut Garut
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : JURNAL KIMIA SAINS DAN APLIKASI

 1 
Cytotoxic Activity of Ethyl-para-methoxycinnamate from Kaempferia galanga L. on A549 Lung Cancer and B16 Melanoma Cancer Cells Riza Apriani; Fajar Fauzi Abdullah
Jurnal Kimia Sains dan Aplikasi Vol 24, No 1 (2021): Volume 24 Issue 1 Year 2021
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3180.598 KB) | DOI: 10.14710/jksa.24.1.22-28

Abstract

Kaempferia galanga L. belongs to the family of Zingiberaceae, an endangered medicinal plant with pharmacology activities. Ethyl-p-methoxycinnamate (EPMC) is an essential phytoconstituent of K. galanga rhizomes. Several studies have reported that EPMC has anticancer activities in several cancer cells, including CL-6 gallbladder cancer cells, HepG2liver cancer cells, MCF-7 breast cancer cells, and Raji lymphoma cancer cells. However, studies on A549 lung cancer and B16 melanoma cancer cells have not been reported. This study aimed to determine the anticancer activity of EPMC against A549 lung cancer and B16 melanoma cancer cells. EPMC was obtained by extraction using n-hexane, then recrystallized with chloroform. The isolate was then analyzed by thin-layer chromatography (TLC), and the structure was characterized by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy. Cytotoxic activity was determined under Presto Blue assay. Based on the result, EPMC from K. galanga showed the cytotoxic effect on B16 cells with an IC50 value of 97.09 μg/mL, whereas EPMC showed no significant cytotoxic effect on A549 with an IC50 value of 1407.75 μg/mL. It was concluded that EPMC has potential cytotoxic on B16 melanoma cancer cells, but it showed inactive activity against A549 lung cancer cells. Further molecular mechanism underlying EPMC cytotoxic activity needs to be conducted.
Co-Authors Agustine Chandra Suryana Ai Eva Aning Suryani Arief Rakhmatuloh Asman Sadino Dhini Anisa Dhini Annisa Rahmasari Kanto Fajar Fauzi Abdullah Fajar Fauzi Abdullah Gun Gun Gumilar Hesti Renggana Iqbal Musthapa Meilia Suherman Mira Ilhami Risa Susanti Shabarni Gaffar Shabarni Gaffar Tati Herlina Tati Herlina Widi Mahrunnisa Pratiwi